If the Instrument setting is deactivated 
Reason 1:
Your instrument is not connecting to the PC
If the instrument does not show as connected (bottom right)
It will be impossible to edit the internal setting or delete data from it.
Connect the instrument, Close the settings windows and reopen the settings menu.
Reason 2 :
You are not logged in with the proper user
The Manager will prevent a user from editing or deleting an other users data or instrument
If the settings is not working, (other than reason 1) You are not logged in with the proper user.
Only the admin user can edit everyone else's data or instrument.
If you are not logged in as the administrator, the USERS menu will be gray out (deactivated)
This is because a user that is not an and administrator do not have permission to edit, modify or delete data from the central database or other users.
What to do
1- Logout out of the Manager
2- Login with admin user
In the login screen, you can scroll through the list of users.
Select the Admin and login to the Manager.
Since one of the Users is the main Admin, and it can't be deleted, one of them will work as the admin.
Once you are logged in as the Main Admin, Click on the Users menu
Item 1 (image below)
The Padlock indicated the Main user. This is the owner of the TripLogik Account.
This user can't be deleted as it's your TripLogik Map account ID.
Item 2 (image below)
This is the administrator Privilege selector.
By checking this setting, it will make the selected user an Admin.
Be aware that any Admin can access everyone's data. Including erasing data, changing passwords, deleting instrument inside other users instrument.